Species differences in the in vitro metabolism of deltamethrin and esfenvalerate : Differential
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Species differences in the in vitro metabolism of deltamethrin and esfenvalerate: differential oxidative and hydrolytic metabolism by humans and rats.
Pyrethroids are neurotoxic pesticides whose pharmacokinetic behavior plays a role in their potency. This study examined the elimination of esfenvalerate and deltamethrin from rat and human liver microsomes. A parent depletion approach in the presence and absence of NADPH was used to assess species differences in biotransformation pathways, rates of elimination, and intrinsic hepatic clearance. ...
متن کاملIdentification of rat and human cytochrome p450 isoforms and a rat serum esterase that metabolize the pyrethroid insecticides deltamethrin and esfenvalerate.
The metabolism of (alphaS)-cyano-3-phenoxybenzyl (1R, 3R)-cis-3-(2,2-dibromovinyl)-2,2-dimethylcyclopropane carboxylate (deltamethrin) and (alphaS)-cyano-3-phenoxybenzyl 2-(4-chlorophenyl)-3-methylbutyrate (esfenvalerate) by rat and human liver microsomes differs with respect to the biotransformation pathway (oxidation versus hydrolysis) responsible for their clearance. This study aims to furth...
متن کاملStructure-activity and interaction effects of 14 different pyrethroids on voltage-gated chloride ion channels.
We have proposed that since the type II pyrethroids deltamethrin and cypermethrin, but not the type I pyrethroid cismethrin act on chloride channels, this could contribute to the bimodal nature of pyrethroid poisoning syndromes. We now examine a wider range of pyrethroid structures on the activity of these calcium-independent voltage-gated maxi-chloride channels. Excised inside-out membrane pat...
متن کاملتأثیرچند حشرهکش فسفره و پایرتروئیدی روی مراحل مختلف رشدی زنبور پارازیتوئید تخم سن گندم Trissolcus grandis (Thom.) (Hymenoptera: Scelionidae)
The egg parasitoids are the major natural enemies of sunn pest and application of selective insecticides is one of the strategies for conservation of natural enemies. The toxicity of five different insecticides used in cereal fields to the parasitized eggs was investigated under laboratory conditions. The insecticide solutions were made based on the recommended field rates. 3-, 5- and 8- day -o...
متن کاملتأثیرچند حشرهکش فسفره و پایرتروئیدی روی مراحل مختلف رشدی زنبور پارازیتوئید تخم سن گندم Trissolcus grandis (Thom.) (Hymenoptera: Scelionidae)
The egg parasitoids are the major natural enemies of sunn pest and application of selective insecticides is one of the strategies for conservation of natural enemies. The toxicity of five different insecticides used in cereal fields to the parasitized eggs was investigated under laboratory conditions. The insecticide solutions were made based on the recommended field rates. 3-, 5- and 8- day -o...
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